How Does Mitragyna Speciosa Effect You?

Mitragynine & 7-Hydroxymitragynine


The two alkaloids mainly responsible for the effects of M. Speciosa, are selective & full agonists of the μ-subtype opioid receptor (MOR). The receptor agonist effect of Kratom alkaloids are antagonized by the opioid receptor antagonist naloxone. In addition, 5-HT2a & postsynaptic α2-adrenergic receptors, as well as neuronal Ca2+ channels are also involved in the unique pharmacological & behavioral activity of Mitragynine. 

It is important to remember that regular Kratom use may produce dependence. The withdrawal symptoms in humans are relatively mild & typically diminish within a week. Craving, weakness and lethargy, anxiety, restlessness, rhinorrhea, myalgia, nausea, sweating, muscle pain, jerky movements of the limbs, tremor as well as sleep disturbances and hallucination may occur. We urge you to take this supplement with caution & care. Avoid abusing this herb at all costs. We only recommend occasional use to prevent dependence. If you notice you have become dependent, or started to show symptoms of dependance, then we strongly urge to lower your dose & slowly taper it down to cold turkey. Kratom should be taken in moderation & not carelessly just because it's an all natural & organic plant.

Due to the 25-28 natural alkaloids in the leaves of M. Speciosa, we get specific benefits & effects from ingesting the plant.

For those interested, we have these active alkaloids listed below:


Mitragynine  - 66% - Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial

7-Hydroxymitragynine - 2% - Analgesic, antitussive, antidiarrheal

Paynantheine - 9% - Smooth muscle relaxer 

Speciogynine - 7% - Smooth muscle relaxer, weak opioid agonist

Mitraphylline - <1% 

Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, immunostimulant, anti-leukemic

Isomitraphylline - <1% - Immunostimulant, anti-leukemic

Speciophylline - <1% - Anti-leukemic

Rhynchophylline - <1% - Vasodilator, antihypertensive, calcium channel blocker, antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic

Isorhynchophylline - <1% - Immunostimulant

Ajmalicine - <1% - Cerebrocirculant, antiaggregant, anti-adrenergic, sedative, anticonvulsant, smooth muscle relaxer

Corynantheidine - <1% - Opioid agonist

Corynoxine A - <1% - Calcium channel blocker, anti-locomotive

Corynoxine B - <1% - Anti-locomotive 

Mitrafoline - <1%

Isomitrafoline - <1%

Oxindale A- <1%

Oxindole B - <1%

Speciofoline - <1% - Analgesic, antitussive

Isospeciofoline - <1%

Ciliaphylline - <1% - Analgesic, antitussive

Mitraciliatine - <1%

Mitragynaline - <1%

Mitragynalinic acid - <1%

Corynantheidalinic acid - <1%







Hooper (1907); Field (1921); Lee et al. (1967); Ponglux et al. (1994) Shellard et al. (1978b); Seaton et al. (1958); Shellard, 1974; Shellard and Philipson (1966); Seaton et al. (1960); Trager et al. (1968) Hemmingway et al. (1975); Takayama et al. (2002) Beckett et al. (1966) Houghton et al. (1991)